The mesenchymal stem cells (MSCs) are a group of stem cells in the bone marrow. They have the ability to differentiate into osteocytes, chondrocytes and adipocytes. Tendon derived stem cells (TDSCs) are a group of stem cells derived from tendon and can differentiate into tenocytes. The differentiation of MSCs and TDSCs is controlled by multiple molecular factors and signaling pathways. I mainly focused on studying the role of non-coding RNAs during TDSCs differentiation into tenocytes.
Non-coding RNAs and lineage decisions in MSCs/TDSCs; differentiation toward tenocytes.
Mechanisms underlying tendon regeneration and fracture healing; evaluation of molecular targets and small molecules.
Translational approaches for inherited blood diseases; preclinical strategies informed by stem-cell engineering.